The Applied Biochemistry analysis group of the University of Alicante (UA), in collaboration with researchers from the Doctor Balmis General University Hospital of Alicante (HGUDB) and the Institute of Health and Biomedical Research of Alicante (Isabial), has recognized the anticancer capability of a pigment current within the salt mines of Santa Pola (Alicante).
This pigment is produced by sure microorganisms, the ‘halophilic archaea’, to be able to defend themselves from the solar and its antitumor capability has been examined in varied sorts of breast most cancers, in line with this discovery, which has been revealed within the prestigious journal of ‘Nature Scientific Report’, as indicated by the tutorial establishment in a press release.
The professor of Biology and director of the UA analysis group, Rosa María Martínez, has detailed that this “necessary discovery” started with the event of Micaela Giani’s doctoral thesis. In it, the already physician demonstrated by way of ‘in vitro’ assessments the antioxidant exercise of the pigment and its impact on enzymes (biocatalysts), that are concerned in pathologies akin to diabetes or metabolic syndrome.
Limit the expansion of breast most cancers
“After publishing these outcomes, it was then that we thought of what would occur if we added the pigment to most cancers cells primarily based on the speculation that, being a pigment with an antioxidant exercise nearly 300 occasions greater than that of different antioxidants, it might restrict the power of those cells to develop and reproduce”, detailed the researcher.
In this second part, the analysis group has labored in collaboration with Dr. Gloria Peiró, HGUDB pathologist and professor within the UA Department of Biotechnology, and Yoel Genaro Montoyo-Pujol, PhD in Experimental and Biosanitary Sciences and in addition a researcher on the UA, each belonging to the Isabial breast most cancers and immunology analysis group.
With this collaboration, the researchers had been capable of confirm ‘in vitro’ the impact of this pigment in cell traces consultant of various intrinsic phenotypes of breast most cancers and a line of wholesome breast tissue.
“It doesn’t trigger injury to any wholesome cells”
“We have reached the conclusion that, at sure doses, the pigment doesn’t trigger any dangerous impact on the wholesome cell, nevertheless it does restrict the expansion capability of the neoplastic cells”, Martínez highlighted. Likewise, he added that this discovering “opens a door to Biomedicine, to the design of latest methods to struggle most cancers primarily based on the usage of pure compounds, which aren’t dangerous to the physique”.
The ‘halophilic archaea’ are extremophile microorganisms that require a hypersaline surroundings to thrive, so they’re primarily present in coastal salt flats, inland salt flats or hyper-salt lakes. These microorganisms synthesize uncommon C50 carotenoid pigments known as bacteriorruberin (BR) and its derivatives monoanhydrobacterioruberin (MABR) and bisanhydrobacterioruberin (BABR).
Based on this discovery, there are a number of phases that have to be developed, starting by increasing the research with completely different cell traces from different sorts of tumors, to proceed with the assessments on tissue samples from biopsies or surgical items. The goal, because the researcher has identified, is to design attainable remedy protocols utilizing this pigment after which transfer on to animal research, earlier than arriving at its scientific use in sufferers.
Topics